Dechallenge in Pharmacovigilance: Meaning, ADR Causality, and ICSR Documentation

Dechallenge

Dechallenge is what you observe after stopping a suspected medicine. If symptoms improve, you gain supportive evidence for causality assessment. However, improvement alone does not prove the drug caused the event. So, document drug action, dates, and outcomes clearly. Then compare with rechallenge, which can strengthen causality when safe and justified.